Publications

Major Contributions

• LM McEwen, KJ O’Donnell, MG McGill, RE Edgar, MJ Jones, JL MacIsaac, DTS Lin, KE Ramadori, AM Morin, N Gladish, E Garg, E Unternaehrer, I Pokhvisneva, N Karnani, MZL Kee, T Klengel, NE Adler, RG Barr, N Letourneau, GF Giesbrecht, JN Reynolds, D Czmara, JM Armstrong, MJ Essex, C de Weerth, R Beijers, MS Tollenaar, B Bradley, T Jovanovic, KJ Ressler, M Steiner, S Entringer, PD Wadhwa, C Buss, NR Bush, EB Binder, WT Boyce, MJ Meaney, S Horvath, MS Kobor. (2019). The PedBE clock estimates DNA methylation age in pediatric buccal cells. Proc Natl Acad Sci U S A. 2019 Oct 14. pii: 201820843. doi: 10.1073/pnas.1820843116.

• LM McEwen, MJ Jones, DTS Lin, RD Edgar, LT Husquin, JL MacIsaac, KE Ramadori, AM Morin, CF Rider, C Carlsten, L Quintana-Murci, S Horvath, MS Kobor. (2018). Systematic evaluation of DNA methylation age estimation with common preprocessing methods and the Infinium MethylationEPIC BeadChip array. Clinical Epigenetics.10(1):123.

• LM McEwen, AM Morin, RD Edgar, JL MacIsaac, MJ Jones, WH Dow, L Rosero-Bixby, MS Kobor, DH Rehkopf. (2017). Differential DNA methylation and lymphocyte proportions in a Costa Rican high longevity region. Epigenetics and Chromatin.10:21.

• LM McEwen, EG Gatev, MJ Jones, JL MacIsaac, MM McAllister, R Goulding, KM Madden, MG Dawes, MS Kobor, MC Ashe. (2017). Epigenetic signatures from a lifestyle intervention for women at midlife: A Pilot RCT. APMN.43(3):233-239</li>

• P Verschoor, LM McEwen, MS Kobor, MB Loeb, DME Bowdish. (2018). DNA methylation patterns are related to co-morbidity status and circulating C-reactive protein levels in the nursing home elderly. Exp Gerontol.105:47-52.

• SR Moore, LM McEwen, J Quirt, A Morin, SM Mah, RG Barr, WT Boyce, MS Kobor. Epigenetic correlates of neonatal contact in humans. (2017). Dev Psychopathol.

• CP Verschoor, LM McEwen, V Kohli, C Wolfson C, DME Bowdish, P Raina, MS Kobor MS, C Balion. (2017). The relation between DNA methylation patterns and serum cytokine levels in communitydwelling adults: a preliminary study. BMC Genetics.18(1):57

• CS Mang, LM McEwen, JL MacIsaac, NH Snow, KL Campbell, MS Kobor, CJD Ross, LA Boyd. Exploring genetic influences underlying acute aerobic exercise effects on motor learning. (2017). Sci Rep. (1):12123.

• AK Beery, LM McEwen, JL MacIsaac, DD Francis, MS Kobor. (2015). Natural variation in maternal care and cross-tissue patterns of oxytocin receptor gene methylation in rats. Hormones and Behavior.</li> 77:42-52.

Co-authored Contributions:

• A Cardenas, S Ecker, RP Fadadu, K Huen, A Orozco, LM McEwen, HR Engelbrecht, N Gladish, MS Kobor, L Rosero-Bixby, WH Dow, DH Rehkopf. (2022). Epigenome-wide association study and epigenetic age acceleration associated with cigarette smoking among Costa Rican adults. Scientific reports, 12(1), 4277. https://doi.org/10.1038/s41598-022-08160-w

• MG McGill, I Pokhvisneva, AS Clappison, LM McEwen, R Beijers, MS Tollenaar, H Pham, M Kee, E Garg, EJ de Mendonça Filho, N Karnani, PP Silveira, MS Kobor, C de Weerth, C., MJ Meaney, & KJ O’Donnell. (2022). Maternal Prenatal Anxiety and the Fetal Origins of Epigenetic Aging. Biological psychiatry, 91(3), 303–312. https://doi.org/10.1016/j.biopsych.2021.07.025

• KA Dill-McFarland, SG König, F Mazel, DC Oliver, LM McEwen, KY Hong, SJ Hallam. (2021). An integrated, modular approach to data science education in microbiology. PLoS Computational Biology, 17(2), e1008661. https://doi.org/10.1016/j.biopsych.2021.07.025

• SA Hari Dass, K McCracken, I Pokhvisneva, LM Chen, E Garg, TTT Nguyen, Z Wang, B Barth, M Yaqubi, LM McEwen, JL MacIsaac, J Diorio, MS Kobor, KJ O’Donnell, MJ Meaney, PP Silveira. (2019). A biologically-informed polygenic score identifies endophenotypes and clinical conditions associated with the insulin receptor function on specific brain regions. EBioMedicine. 42:188-202.

• LT Husquin, M Rotival, M Fagny, H Quach, N Zidane, LM McEwen, JL MacIsaac, MS Kobor, H Aschard, E Patin, L Quintana-Murci. (2018). Exploring the genetic basis of human population differences in DNA methylation and their causal impact on immune gene regulation. Genome Biol. 19(1):222.

• NR Bush, RD Edgar, M Park, JL MacIsaac, LM McEwen, NE Adler, MJ Essex, MS Kobor, WT Boyce. (2018). The biological embedding of early-life socioeconomic status and family adversity in children’s genome-wide DNA methylation. Epigenomics.(11):1445-1461.

• LM Chen, N Yao, E Garg, Y Zhu, TTT Nguyen, I Pokhvisneva, SA Hari Dass, E Unternaehrer, H Gaudreau, M Forest,LM McEwen, JL MacIsaac, MS Kobor, CMT Greenwood, PP Silveira, MJ Meaney, KJ O’Donnell. (2018). PRS-on-Spark (PRSoS): a novel, efficient and flexible approach for generating polygenic risk scores. BMC Bioinformatics. 19(1):295.

• E Garg, L Chen, TTT Nguyen, I Pokhvisneva, LM Chen, E Unternaehrer, JL MacIsaac, LM McEwen, SM Mah, H Gaudreau, R Levitan, E Moss, MB Sokolowski, JL Kennedy, MS Steiner, MJ Meaney, JD Holbrook, PP Silveira, N Karnani, MS Kobor, KJ O’Donnell; Mavan Study Team. (2018). The early care environment and DNA methylome variation in childhood. Dev Psychopathol. 30(3):891:903.

• MK Austin, E Chen, KM Ross, LM McEwen, JL Maclsaac, MS Kobor, GE Miller. (2018). Early-life socioeconomic disadvantage, not current, predicts accelerated epigenetic aging of monocytes. Psychoneuroendocrinology.97:131-134.

• RL Clifford, N Fishbane, J Patel, JL MacIsaac, LM McEwen, AJ Fisher, CA Brandsma, P Nair, MS Kobor, TL Hackett, AJ Knox. (2018). Altered DNA methylation is associated with aberrant gene expression in parenchymal but not airway fibroblasts isolated from individuals with COPD. Clinical Epigenetics.10:32.

• M Forest, KJ O’Donnell, G Voisin, H Gaudreau, JL MacIsaac, LM McEwen, PP Silveira, M Steiner, MS Kobor, MJ Meaney, CMT Greenwood. (2018). Agreement in DNA methylation levels from the Illumina 450K array across batches, tissues, and time. Epigenetics. 2018;13(1):19-32.

• KJ O’Donnell, L Chen, JL MacIsaac, LM McEwen, T Nguyen, K Beckmann, Y Zhu, LM Chen, J Brooks-Gunn, D Goldman, EL Grigorenko, JF Leckman, J Diorio, N Karnani, DL Olds, JD Holbrook, MS Kobor, MJ Meaney. (2018). DNA methylome variation in a perinatal nurse-visitation program that reduces child maltreatment: a 27-year follow-up. Transl Psychiatry. 7(8):e1223.

• M Morin, E Gatev, LM McEwen, JL MacIsaac, DTS Lin, N Koen, D Czamara, K Räikkönen, HJ Zar, K Koenen, DJ Stein, MS Kobor, M Jones. (2017). Maternal blood contamination of collected cord blood can be identified using DNA methylation at three CpGs. Clinical Epigenetics.9:75.

• S Gopalan, O Carja, M Fagny, E Patin, JW Myrick, LM McEwen, SM Mah, MS Kobor, A Froment, MW Feldman, L Quintana-Murci, BM Henn. (2017). Trends in DNA methylation with age replicate across diverse human populations. Genetics. 206(3):1659-1674.

Abstracts & Book Chapters:

• LM McEwen, JC O’Donnell, L Lifoawing, D Matias, B Wagar. (2019). Electronic Physician Profiles: Developing an Interactive Web-Based Report for Physicians at Island Health. Stud Health Technol Inform. 257:310-313.

• LM McEwen, SJ Goodman, MS Kobor, MJ Jones. 2017. The DNA Methylome: An Interface Between the Environment, Immunity, and Ageing. The Ageing Immune System and Health. 35-52.

You can also find my articles on my Google Scholar profile.